LC

Lynne Chou O'Keefe

VC

Founder & Managing Partner, Define Ventures

Digital health pioneer and early-stage VC founder

San Francisco, CA4 notable investments
Pre-SeedSeedSeries A
HealthcareAIConsumerEnterprise SaaS

Background

Lynne Chou O'Keefe is the Founder and Managing Partner of Define Ventures, which she founded in 2019. The firm manages $800 million in assets and has generated $23 billion in exit value through companies like Hims & Hers (HIMS), Livongo (LVGO), and Evolent (EVH). Previously she was a Senior Partner at Kleiner Perkins focused on digital health and connected devices, and earlier worked at Abbott Vascular, Goldman Sachs M&A, and Apax Partners. She holds a BS in Industrial Engineering from Stanford and an MBA from Harvard Business School.

Investment Thesis

Early-stage digital health companies from inception through Series B that are building category-defining healthcare businesses.

Investment Focus

Stages

Pre-SeedSeedSeries A

Sectors

HealthcareAIConsumerEnterprise SaaS

Based in: San Francisco, CA (North America)

Notable Investments

Last updated: Jun 11, 2026